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Fumaria



Interactions

Fumaria/Drug Interactions:
  • Acne medicationAcne medication: A lotion containing tinctures of calendula and fumaria was reported to be beneficial for the treatment of juvenile acne (22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species. An in vitro study suggested that sanguinarine has the potential to be an effective antiplatelet agent (28).
  • AntifungalsAntifungals: In an in vitro study, fumaria alkaloid derivative displayed significant antifungal activity at 8mcg/mL concentration (24).
  • Anti-inflammatory agentsAnti-inflammatory agents: In animal models, fumaria was reported to have anti-inflammatory activity (27).
  • AntineoplasticsAntineoplastics: Fumaria has been reported to have antineoplastic effects in human and rat studies (43; 44). In laboratory study, Fumaria parviflora extract has been shown to modulate critical events regulating pro- and anti-apoptotic proteins in mitochondria-dependent apoptosis induced by nimesulide (45).
  • AntiparasiticsAntiparasitics: In animal studies, fumaria has been reported to have antiparasitic activity (25; 26).
  • AntipyreticsAntipyretics: A rabbit study found antipyretic effects by Fumaria parviflora comparable in potency to aspirin (46).
  • AntispasmodicsAntispasmodics: In vitro studies using rodent small intestine noted that the crude whole plant extract of Fumaria indica and its fractions had spasmogenic and spasmolytic effects (29).
  • AntiviralAntiviral: Fumaria might potentiate antiviral and antifungal drugs. An in vitro study reported that fumaria alkaloid derivative did not present any notable antibacterial effect; however, they had significant antifungal activity at 8mcg/mL concentration. Seven derivatives of alkaloids obtained from some Fumaria and Corydalis species growing in Turkey were evaluated for their in vitro antiviral and antimicrobial activities(24).
  • Cardiovascular drugsCardiovascular drugs: Theoretically, based on alkaloid constituents, fumaria may interact with cardioactive drugs.
  • Cholinesterase inhibitorsCholinesterase inhibitors: Fumaria was reported to have anticholinesterase activity in in vitro studies (47).
  • CNS depressantsCNS depressants: Fumaria might potentiate the central nervous system (CNS) depressants. An in vitro and a rat study reported CNS depressant activity from fumaria alkaloids (6; 32).

Fumaria/Herb/Supplement Interactions:
  • Acne herbsAcne herbs: A lotion containing tinctures of calendula and fumaria was reported to be beneficial for the treatment of juvenile acne (22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species. An in vitro study suggested that sanguinarine has the potential to be an effective antiplatelet agent (28).
  • AntifungalsAntifungals: In an in vitro study, fumaria alkaloid derivative displayed significant antifungal activity at 8mcg/mL concentration (24).
  • Anti-inflammatory herbsAnti-inflammatory herbs: In animal models, fumaria was reported to have anti-inflammatory activity; therefore, it might increase the effectiveness of anti-inflammatory drugs (27).
  • AntineoplasticsAntineoplastics: Fumaria has been reported to have antineoplastic effects in human and rat studies; therefore, it might augment the effects of anticancer drugs (43; 44).
  • AntiparasiticsAntiparasitics: In animal studies, fumaria has been reported to have antiparasitic activity (25; 26).
  • AntipyreticsAntipyretics: A rabbit study found antipyretic effects by Fumaria parviflora comparable in potency to aspirin (46).
  • AntispasmodicsAntispasmodics: In vitro studies using rodent small intestine noted that the crude whole plant extract of Fumaria indica and its fractions had spasmogenic and spasmolytic effects (29).
  • Cardioactive herbs and supplementsCardioactive herbs and supplements: Theoretically, based on alkaloid constituents, fumaria may interact with cardioactive herbs and supplements.
  • CholinergicsCholinergics: Fumaria was reported to have anticholinesterase activity in in vitro studies (47).
  • SedativesSedatives: Fumaria might potentiate the CNS depressants. An in vitro and a rat study reported CNS depressant activity from fumaria alkaloids (6; 32).

Fumaria/Food Interactions:
  • Insufficient available evidence.

Fumaria/Lab Interactions:
  • Cholinesterase levelCholinesterase level: An in vitro study reported that fumaria possessed anticholinesterase activity; it displayed highly potent inhibition compared to the standard at a 1mg/mL concentration (47); therefore, fumaria might lower serum cholinesterase levels.
  • Coagulation panelCoagulation panel: Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species. An in vitro study suggested that sanguinarine has the potential to be an effective antiplatelet agent (28); therefore, it might decrease platelet aggregation.
  • Liver function testsLiver function tests: In vitro studies have reported that fumaria lowered liver enzymes such as SGOT and SGPT (34; 35; 36; 37; 38).

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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