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Umckaloabo(Pelargonium sidoides)



Interactions

Umckaloabo/Drug Interactions:
  • AntibioticsAntibiotics: Based on in vitro study, umckaloabo may exert antibacterial effects against a wide range of gram-negative and gram-positive bacteria (17; 4; 12; 13; 18; 14; 19; 20). The effects of umckaloabo with antibiotics are not well understood.
  • Anticoagulants/antiplateletsAnticoagulants/antiplatelets: Based on in vitro study, umckaloabo contains coumarin, a natural anticoagulant, as one of its main constituents (4). Theoretically, concurrent use of anticoagulants or antiplatelets and umckaloabo may increase the risk of bleeding.
  • Cardiovascular agentsCardiovascular agents: Based on human case reports, umckaloabo may cause tachycardia, and theoretically may alter the effects of cardiovascular agents (16).
  • Hepatotoxic agentsHepatotoxic agents: Umckaloabo contains coumarin (4) which may cause hepatotoxicity when consumed in large amounts. Theoretically, concurrent use of hepatotoxic agents and umckaloabo may increase the risk of liver damage.
  • ImmunosuppressantsImmunosuppressants: Based on in vitro studies, umckaloabo may have immunostimulant effects (8; 21; 4; 17; 22; 23; 24). Theoretically, umckaloabo may interfere with the effects of immunosuppressants.
  • LaxativesLaxatives: Based on human study, umckaloabo may cause a laxative effect (16). Theoretically, concurrent use of umckaloabo and laxatives may cause additive effects.

Umckaloabo/Herb/Supplement Interactions:
  • Antibacterials Antibacterials : Based on in vitro study, umckaloabo may exert antibacterial effects (17; 4; 12; 13; 18; 14; 19; 20). The effects of umckaloabo with antibacterial agents are not well understood.
  • Anticoagulants/antiplateletsAnticoagulants/antiplatelets: Based on in vitro study, umckaloabo contains coumarin, a natural anticoagulant, as one of its main constituents (4). Theoretically, concurrent use of anticoagulants or antiplatelets and umckaloabo may increase the risk of bleeding .
  • Cardiovascular herbs and supplementsCardiovascular herbs and supplements: Based on human case reports, umckaloabo may cause tachycardia, and theoretically may alter the effects of cardiovascular agents (16).
  • Hepatotoxic agentsHepatotoxic agents: Umckaloabo contains coumarin (4), which may cause hepatotoxicity when consumed in large amounts. Theoretically, concurrent use of hepatotoxic agents and umckaloabo may increase the risk of liver damage.
  • ImmunosuppressantsImmunosuppressants: Based on in vitro studies, umckaloabo may have immunostimulant effects (8; 21; 4; 17; 22; 23; 24). Theoretically, umckaloabo may interfere with the effects of immunosuppressants.
  • LaxativesLaxatives: Based on human study, umckaloabo may cause a laxative effect (16). Theoretically, concurrent use of umckaloabo and laxatives may cause additive effects.

Umckaloabo/Food Interactions:
  • Insufficient evidence available.

Umckaloabo/Lab Interactions:
  • Bacterial culturesBacterial cultures: Based on in vitro study, umckaloabo may exert antibacterial effects against a wide range of gram-negative and gram-positive bacteria (17; 4; 12; 13; 18; 14; 19; 20).
  • Coagulation panelCoagulation panel: Based on in vitro study, umckaloabo contains coumarin, an anticoagulant, as one of its main constituents (4).
  • Heart rateHeart rate: Based on human case reports, umckaloabo may cause tachycardia (16).
  • Immune panelImmune panel: In vitro studies indicate that Pelargonium sidoides may increase immune function (8; 21; 4; 17; 22; 23).
  • Liver function testsLiver function tests: Umckaloabo contains coumarin (4), which may cause hepatotoxicity and elevated liver enzymes when consumed in large amounts.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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